(+)-N-Allylnormetazocine hydrochloride_product_DataBase

Bioactivity	(+)-N-Allylnormetazocine ((+)-SKF 10047) hydrochloride is a benzomorphan opioid with psychotomi metic effects. (+)-N-Allylnormetazocine hydrochloride is an opioid receptor antagonist with Ki values of 300 nM and 27 μM for σ1 and σ2 opioid receptors, respectively. (+)-N-Allylnormetazocine hydrochloride can be used for the research of neurological disease[1][2].
Invitro	(+)-N-Allylnormetazocine hydrochloride (1 nM) 对 µ，δ 和 κ 阿片受体的抑制率分别为 28.5%，2.5% 和 31%[1]。(+)-N-Allylnormetazocine hydrochloride 对 σ1 和 σ2 阿片受体的 Ki 值分别为 300 nM 和 27 μM[1]。
In Vivo	(+)-N-Allylnormetazocine hydrochloride (0.3，1，3，10 和 30 mg/kg；腹腔注射，每次实验前10 分钟) 剂量依赖性地增加解离性麻醉药苯环利定 (PCP) 的反应[2]。
Name	(+)-N-Allylnormetazocine hydrochloride
CAS	133005-41-1
Formula	C17H24ClNO
Molar Mass	293.83
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. May EL, et al. Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues. J Med Chem. 2000 Dec 28;43(26):5030-6. [2]. Brady KT, et al. Stereoisomers of N-allylnormetazocine: phencyclidine-like behavioral effects in squirrel monkeys and rats. Science. 1982 Jan 8;215(4529):178-80.

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