| Bioactivity | Nauclefine is an indole alkaloid isolated from Nauclea officinalis. Nauclefine acts as a PDE3A modulator to induce cancer cell apoptosis through a PDE3A-SLFN12-dependent death pathway[1]. |
| Invitro | Nauclefine (250 nM, 48 h) 可以抑制 HeLa 细胞活力，并诱导细胞凋亡，造成细胞 PDE3A 和 SLFN12 依赖性死亡。Nauclefine 可以结合 PDE3A，但不抑制其磷酸二酯酶活性，能够促进 PDE3A 和 SLFN12 之间的相互作用，并通过增加 SLFN12 的稳定性促进细胞死亡[1]。 |
| Name | Nauclefine |
| CAS | 57103-51-2 |
| Formula | C18H13N3O |
| Molar Mass | 287.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Nauclefine
CAS: 57103-51-2 F: C18H13N3O W: 287.32
Nauclefine is an indole alkaloid isolated from Nauclea officinalis. Nauclefine acts as a PDE3A modulator to induce cance
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