INCB3619_product_DataBase

CAS: 791826-72-7 F: C22H27N3O5 W: 413.47

INCB3619 is a selective and orally active ADAM inhibitor with IC50 of 22 nM and 14 nM for ADAM10 and ADAM17, respectivel

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	INCB3619 is a selective and orally active ADAM inhibitor with IC50 of 22 nM and 14 nM for ADAM10 and ADAM17, respectively. INCB3619 has anti-tumor activity[1].
Invitro	INCB3619 (0-0.25 μM, 96 h) 可以抑制 heregulin 依赖性 HER3-Akt 通路，但不能抑制 A549 细胞中的 ERK 活性，可诱导 A549 细胞凋亡[1]。 INCB3619 (0-10 μM, 72 h) 可以抑制 EGFR 自分泌细胞系 NCI-H1666 中的 EGFR 配体信号传导，并可与其他抗 EGFR 药物，如吉非替尼联合使用[1]。INCB3619 (2 µM) 抑制 NCI-H166 细胞中 ERK1/2 的表达，使其对吉非替尼 (Gefitinib，HY-50895) 敏感[1]。 Apoptosis Analysis[1]. Cell Line:
Name	INCB3619
CAS	791826-72-7
Formula	C22H27N3O5
Molar Mass	413.47
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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