| Bioactivity | EGFR-IN-47 is a potent and orally active EGFRL858R/T790M/C797S inhibitor with an IC50 of 0.01 µM. EGFR-IN-47 induces cell cycle attest and cell apoptosis. EGFR-IN-47 has the potential for the research of NSCLC[1]. |
| Invitro | EGFR-IN-47 (compound 14aj) (72 h) shows anti-proliferative effects with IC50s of 0.013 µM, 2.972 µM, 1.031 µM for PC-9 (EGFRL858R/T790M/C797S), A432, A549 cells, respectively[1].EGFR-IN-47 (0.01, 0.05, 0.25, 1 µM; 24 h) induces cell cycle attest at the G0/G1-phase[1].EGFR-IN-47 (0.01, 0.05, 0.25 µM) induces cell deathvia apoptosis in a concentration-dependent manner[1].EGFR-IN-47 (0.01, 0.05, 0.25, 1 µM) inhibits phosphorylation of the EGFR downstream mediators[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | EGFR-IN-47 |
| Formula | C29H35N7 |
| Molar Mass | 481.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |