| Bioactivity | NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway. |
| Target | ZIP7. |
| Invitro | NVS-ZP7-4 increases ER zinc levels, suggesting functional modulation of ZIP7[1]. |
| Name | NVS-ZP7-4 |
| CAS | 2349367-89-9 |
| Formula | C28H28FN5OS |
| Molar Mass | 501.62 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Nolin E, et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat Chem Biol. 2019 Feb;15(2):179-188. |
NVS-ZP7-4
CAS: 2349367-89-9 F: C28H28FN5OS W: 501.62
NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impa
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