Dexamethasone palmitate_product_DataBase

Bioactivity

Dexamethasone palmitate (DXP) is a prodrug of Dexamethasone (HY-14648). Dexamethasone palmitate can be used for the research of inflammation[1][2].

Invitro

Dexamethasone palmitate (100 μg/mL; 48 h) affects cytokines concentration of RAW 264.7 cells[1]. Cell Viability Assay[1] Cell Line:

In Vivo

Dexamethasone palmitate (1280 μg; IVT injection once) shows different distribution in ocular tissue at different times[2].Dexamethasone palmitate (280-1280 μg; IVT injection once) affects VEGF-induced vascular hyperpermeability[2]. Animal Model:

Name

Dexamethasone palmitate

CAS

14899-36-6

Formula

C38H59FO6

Molar Mass

630.87

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Lorscheider M, et al. Dexamethasone palmitate nanoparticles: An efficient treatment for rheumatoid arthritis. J Control Release. 2019 Feb 28;296:179-189. [2]. Daull P, et al. A preliminary evaluation of dexamethasone palmitate emulsion: a novel intravitreal sustained delivery of corticosteroid for treatment of macular edema. J Ocul Pharmacol Ther. 2013 Mar;29(2):258-69.

PeptideDB

Dexamethasone palmitate

CAS: 14899-36-6 F: C38H59FO6 W: 630.87