| Bioactivity | ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates[1]. | ||||||||||||
| Target | ERAP1 | ||||||||||||
| Invitro | ERAP1-IN-1 (compound 3) allosterically activates ERAP1’s hydrolysis of fluorogenic and chromogenic amino acid substratesv[1].ERAP1-IN-1 (50 µM) exhibits specific inhibition of ERAP1 in the cellular context[1]. | ||||||||||||
| Name | ERAP1-IN-1 | ||||||||||||
| CAS | 865273-97-8 | ||||||||||||
| Formula | C20H21F3N2O5S | ||||||||||||
| Molar Mass | 458.45 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Maben Z, et al. Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1. J Med Chem. 2019 Dec 30. |
ERAP1-IN-1
CAS: 865273-97-8 F: C20H21F3N2O5S W: 458.45
ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activ
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