| Bioactivity | NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor (IC50= 574 nM) that acts independently of Ca2+. NLRP3-IN-NBC6 inhibits Nigericin (HY-127019)-induced inflammasome activation in THP-1 cells and Imiquimod (HY-B0180)-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs)[1]. | ||||||||||||
| Invitro | In LPS-primed primary BMDMs, NLRP3-IN-NBC6 (10 μM; 15 minutes) inhibits Imiquimod-induced IL-1β release. NLRP3-IN-NBC6 completely inhibits NLRP3-dependent IL-1β release in neutrophils (neutrophils were isolated from WT and NLRP3 KO murine bone marrow and primed with LPS followed by Nigericin treatment in the presence of 10 μM NLRP3-IN-NBC6)[1]. | ||||||||||||
| Name | NLRP3-IN-NBC6 | ||||||||||||
| CAS | 2068818-02-8 | ||||||||||||
| Formula | C18H16BCl3N2O2 | ||||||||||||
| Molar Mass | 409.50 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Baldwin AG, et al. Boron-Based Inhibitors of the NLRP3 Inflammasome. Cell Chem Biol. 2017;24(11):1321-1335.e5. |
NLRP3-IN-NBC6
CAS: 2068818-02-8 F: C18H16BCl3N2O2 W: 409.50
NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor (IC50= 574 nM) that acts independently of Ca2+. N
Data collection：peptidedb@qq.com
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