| Bioactivity | 15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation[1]. | ||||||||||||
| Invitro | 15-LOX-1 inhibitor 1 (Compound 9c) (0-5 μM; 24 hours) protects RAW 264.7 macrophages from LPS-induced cell death and shows stronger, dose-dependent effects with a 20% viability increase at 5 μM[1]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | 15-LOX-1 inhibitor 1 | ||||||||||||
| CAS | 2349374-37-2 | ||||||||||||
| Formula | C22H21ClN2O4 | ||||||||||||
| Molar Mass | 412.87 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Guo H, et al. Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity. J Med Chem. 2019;62(9):4624-4637. |
15-LOX-1 inhibitor 1
CAS: 2349374-37-2 F: C22H21ClN2O4 W: 412.87
15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhi
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