| Bioactivity | NCC-149 is a selective HDAC8 inhibitor and can be used for neural differentiation research[1]. | ||||||||||||
| Invitro | NCC-149 (5 μM; 3 days) remarkably reduces NeuN expression levels in P19 cells[1].NCC-149 (0-40 μM; 4 days) reduces embryoid body size in a dose-dependent manner[1].NCC-149 (5 and 20 μM; 24 h) downregulates P19 cell proliferation[1].NCC-149 (2.5 and 5 μM; 24 h) leads to cell growth retardation by G2/M phase arrest[1]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | NCC-149 | ||||||||||||
| CAS | 1316652-41-1 | ||||||||||||
| Formula | C16H14N4O2S | ||||||||||||
| Molar Mass | 326.37 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Katayama S, et al. HDAC8 regulates neural differentiation through embryoid body formation in P19 cells. Biochem Biophys Res Commun. 2018 Mar 25;498(1):45-51. |