| Bioactivity | PF-04449613 is a selective PDE9A inhibitor with an IC50 of 22 nM[1]. PF-04449613 improved motor learning ability in a mouse model[2]. |
| Name | PF-04449613 |
| CAS | 1236858-52-8 |
| Formula | C21H25N5O3 |
| Molar Mass | 395.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Claffey MM, et al. Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. J Med Chem. 2012 Nov 8;55(21):9055-68. [2]. Lai B, et al. The Phosphodiesterase 9 Inhibitor PF-04449613 Promotes Dendritic Spine Formation and Performance Improvement after Motor Learning. Dev Neurobiol. 2018 Sep;78(9):859-872. |
PF-04449613
CAS: 1236858-52-8 F: C21H25N5O3 W: 395.45
PF-04449613 is a selective PDE9A inhibitor with an IC50 of 22 nM. PF-04449613 improved motor learning ability in a mouse
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