| Bioactivity | DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer[1][2]. | ||||||||||||
| Target | KV7 channel | ||||||||||||
| Invitro | DMP-543 enhances [3H]ACh release from rat brain slices, with an EC50 of 700 nM[2]. | ||||||||||||
| Name | DMP-543 | ||||||||||||
| CAS | 160588-45-4 | ||||||||||||
| Formula | C26H18F2N2O | ||||||||||||
| Molar Mass | 412.43 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Ipavec V, et al. KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus. Pharmacol Res. 2011 Oct;64(4):397-409. [2]. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30. |