| Bioactivity | Mps1-IN-6 is a potent Mps1 inhibitor with an IC50 value of 2.596 nM. Mps1-IN-6 shows antiproliferative activity. Mps1-IN-6 shows antitumor activity[1]. |
| Target | IC50: 2.596 nM (Mps1) |
| Invitro | Mps1-IN-6 (compound 31) (0-10 µM; 72 h) 显示抗增殖活性，对于 MDA-MB-468，MCF-7, REB，MV4-11，HT-29 细胞的 IC50 值分别为 0.221, >10, >10, 0.823, >10 µM[1]。 Cell Proliferation Assay[1] Cell Line: |
| In Vivo | Mps1-IN-6 (30, 60 mg/kg; i.v.; once daily for 21 days) 在小鼠体内显示出抗肿瘤活性[1]。 Animal Model: |
| Name | Mps1-IN-6 |
| Formula | C35H39N9O3 |
| Molar Mass | 633.74 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shihe Hu, et al. Discovery of pyrazolo[3,4-b]pyridine derivatives as novel and potent Mps1 inhibitors for the treatment of cancer. European Journal of Medicinal Chemistry. 2023, 253: 115334. |