| Bioactivity | CRT 0105446 (compound 22d) is a LIMK1 inhibitor, with an IC50 of 8 nM[1]. |
| Invitro | CRT 0105446 (compound 22d) 在浓度为3 µM 时抑制了细胞穿过基质蛋白凝胶的入侵，而即使在更高的化合物浓度10 µM下，也没有显着影响细胞存活率[1]。 |
| Name | CRT 0105446 |
| CAS | 1661846-05-4 |
| Formula | C20H18F3N3O2S |
| Molar Mass | 421.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mark D Charles, et al. Discovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties. J Med Chem. 2015 Oct 22;58(20):8309-13. |