Moroidin_product_DataBase

Bioactivity	Moroidin is a tubulin polymerization inhibitor and has a potent inhibitory effect on purified tubulin polymerization. Moroidin is a bicyclic octapeptide belonging to the Urticaceae-type cyclopeptide family. Moroidin has cytotoxic effects for several cancer cells and can induce apoptosis in A549 human lung cancer cells[1].
Invitro	Moroidin (compound 1) (0-80 μM; 24, 48, or 72 h) has cytotoxicity to cancer cells with IC50 values of 3.2, 8.3, 9.6, 5.2 and 9.9 μM in A549, H1299, U87, U251 and HCT116 cells, respectively[1].Moroidin (0.01-100 μM; 24 h, 48 h, 72 h) interferes with microtubule polymerization and decreases β-tubulin protein levels in A549 cells[1].Moroidin (0-20 μM; 48 h) arrests the cell cycle in the G2/M phase and induces apoptosis in A549 cells[1].Moroidin (0.5, 1, 2 μM; 0, 24, 48 h) represses the migration and invasion of A549 cells[1]. Cell Viability Assay[1] Cell Line:
Name	Moroidin
CAS	104041-75-0
Formula	C47H66N14O10
Molar Mass	987.11
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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