| Bioactivity | c-Met/HDAC-IN-2 is a highly potent c-Met and HDAC dual inhibitor with IC50s of 18.49 nM and 5.40 nM for HDAC1 and c-Met, respectively. c-Met/HDAC-IN-2 has antiproliferative activities against certain cancer cell lines. c-Met/HDAC-IN-2 can cause G2/M-phase arrest and induce apoptosis in HCT-116. c-Met/HDAC-IN-2 can be used for researching anti-cancer resistance[1]. |
| Invitro | c-Met/HDAC-IN-2 (compound 14X) (0-20 μM; 72 hours) exhibits antiproliferative activities against HCT-116, MCF-7 and A549[1].c-Met/HDAC-IN-2 (0.2-5 μM; 48 hours) induces of cancer cell apoptosis in a dose-dependent manner[1].c-Met/HDAC-IN-2 (0.2-5 μM; 48 hours) significantly causes G2/M-phase arrest in HCT-116 cells in a dose dependent manner[1]. Cell Proliferation Assay Cell Line: |
| Name | c-Met/HDAC-IN-2 |
| CAS | 2740495-53-6 |
| Formula | C34H33N5O7 |
| Molar Mass | 623.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
c-Met/HDAC-IN-2
CAS: 2740495-53-6 F: C34H33N5O7 W: 623.66
c-Met/HDAC-IN-2 is a highly potent c-Met and HDAC dual inhibitor with IC50s of 18.49 nM and 5.40 nM for HDAC1 and c-Met,
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