Mca-(ala7,lys(dnp)9)-bradykinin

CAS: 323577-36-2 F: C66H81N15O19 W: 1388.44

Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The inc

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Bioactivity	Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage[1].
Invitro	Mca-(ala7,lys(dnp)9)-bradykinin is also a substrate for neprilysin, but is hydrolyzed 10-fold more efficiently by ECE-1, making this substrate selective for ECE-1[1].
Name	Mca-(ala7,lys(dnp)9)-bradykinin
CAS	323577-36-2
Shortening	{MOCAc}-RPPGFSAFK-{DNP}
Formula	C66H81N15O19
Molar Mass	1388.44
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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