| Bioactivity | Maytansinoid B is a kind of ADC Cytotoxin. Maytansinoid B can be used to conjugates with antibodies to form antibody-drug conjugates (ADCs). Maytansinoids are known as antimitotic agents, binding to tubulin and inhibiting microtubule assembly. Maytansinoids induces G2/M arrest in the cell cycle to induce apoptosis[1][2]. | ||||||||||||
| Invitro | Maytansinoid 对包括淋巴瘤系在内的几种肿瘤细胞系表现出 10-90 pM 的细胞毒活性[1]。Maytansinoid 与抗 CD9 抗体结合，可形成 SAR3419 对抗 B 细胞恶性肿瘤[1]。 | ||||||||||||
| Name | Maytansinoid B | ||||||||||||
| CAS | 1628543-40-7 | ||||||||||||
| Formula | C36H51ClN4O10 | ||||||||||||
| Molar Mass | 735.26 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Blanc V, et al. SAR3419: an anti-CD19-Maytansinoid Immunoconjugate for the treatment of B-cell malignancies. Clin Cancer Res. 2011 Oct 15;17(20):6448-58. [2]. Andreev Julian, et al. Bispecific antigen binding molecules that bind HER2, and methods of use thereof: World Intellectual Property Organization, WO2021174113. 2021-09-02. |
Maytansinoid B
CAS: 1628543-40-7 F: C36H51ClN4O10 W: 735.26
Maytansinoid B is a kind of ADC Cytotoxin. Maytansinoid B can be used to conjugates with antibodies to form antibody-dru
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