| Bioactivity | SG-094 is a potent TPC2 inhibitor with antiproliferative effects. SG-094 can be used for the research of cancer[1]. |
| Target | TPC2 |
| Invitro | SG-094 (72 hours) 显示出对 RIL175 细胞的抗增殖作用，IC50 值为 3.7 μM[1]。SG-094 (10 μM) 阻断从表达 TPC2-EGFP 的 HEK293 细胞中分离的内溶酶体上 PI(3,5)P2 引发的 TPC2 电流[1]。SG-094 (10 μM; pretreated for 1 h) 显着降低 HUVEC 中 VEGF 诱导的 eNOS，JNK，MAPK 和 AKT 磷酸化，而不降低它们的总蛋白水平[1]。SG-094 (1-5 μM; pretreated for 1 h) 增加葡萄糖饥饿后 RIL175 WT 细胞的 OCR/ECAR 比率[1]。 Western Blot Analysis[1] Cell Line: |
| In Vivo | SG-094 (90 nmol/kg; every 2-3 days over a 10-day timescale) 抑制小鼠的肝细胞癌 (HCC) 肿瘤生长[1]。 Animal Model: |
| Name | SG-094 |
| Formula | C30H29NO3 |
| Molar Mass | 451.56 |
| Appearance | Oil |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Müller M, et, al. Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth. Cell Chem Biol. 2021 Aug 19;28(8):1119-1131.e27. |