MS023 trihydrochloride_product_DataBase

Bioactivity	MS023 trihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1].
Invitro	MS023 dihydrochloride (1-1000 nM；48 小时) 抑制 MCF7 细胞中的 PRMT1 甲基转移酶活性[1]。 MS023 dihydrochloride (1-1000 nM；20 小时) 抑制 HEK293 细胞中的 PRMT6 甲基转移酶活性[1]。 Western Blot Analysis[1] Cell Line:
In Vivo	MS023 dihydrochloride (160 mg/kg，ip) 与 PKC412 (100 mg/kg，ig) 联合给药，通过抑制功能性 MLL-r ALL 起始细胞的维持来阻断 MLL-r 急性淋巴细胞白血病 (ALL) 的传播[2]。 Animal Model:
Name	MS023 trihydrochloride
CAS	2108631-19-0
Formula	C17H28Cl3N3O
Molar Mass	396.78
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11(3):772-81. [2]. Yinghui Zhu, et al. Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia. Blood. 2019 Oct 10;134(15):1257-1268.

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