(S)-Oxiracetam_product_DataBase

Bioactivity	(S)-oxiracetam (S-ORC) is an inhibitor targeting apoptosis. S-ORC reduces brain infarct size and lessens neurological dysfunction in middle cerebral artery occlusion/reperfusion (MCAO/R) models. S-ORC prevents neuronal apoptosis via activating PI3K/Akt/GSK3β signaling pathway via α7 nAChR after ischemic stroke. S-ORC can prevent neuronal death after ischemic stroke[1].
Invitro	(S)-Oxiracetam (1，10，100 μM；24 h) 保护胎鼠原代皮层神经元免受 OGD/R 损伤并激活 PI3K/Akt/GSK3β 信号通路依赖于 α7 nAChR[1]。 Cell Viability Assay[1] Cell Line:
In Vivo	(S)-Oxiracetam (0.12，0.24，0.48 g/kg；静脉注射，每天一次持续 7 天) 在雄性 Sprague-Dawley 大鼠诱导的 MACO/R 模型中，显著减少梗死面积，减轻行为功能障碍，抑制神经元凋亡并激活 PI3K/Akt/GSK3β 信号通路[1]。 Animal Model:
Name	(S)-Oxiracetam
CAS	88929-35-5
Formula	C6H10N2O3
Molar Mass	158.16
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Fan W, et al. S-oxiracetam ameliorates ischemic stroke induced neuronal apoptosis through up-regulating α7 nAChR and PI3K / Akt / GSK3β signal pathway in rats. Neurochem Int. 2018 May;115:50-60.

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