| Bioactivity | MRS 1477, a dihydropyridine derivative, is a positive allosteric modulator of TRPV1 in the presence of capsaicin. MRS 1477 itself does not induce apoptosis, but the co-existence of MRS 1477 and capsaicin can induce apoptosis[1][2]. |
| Invitro | MRS1477 在 MCF7 乳腺癌细胞中激发 Ca22+ 信号，但在原代乳腺上皮细胞中没有[1]。MRS1477 (2 μM; 72 h) 与 capsaicine (10 μM) 一起诱导细胞凋亡并增加活性氧的产生和半胱天冬酶活性[1]。MRS1477 (2 μM) 增加 capsaicine 诱发的 TRPV1 介导的电流密度水平[1]。 |
| Name | MRS 1477 |
| CAS | 212200-21-0 |
| Formula | C21H27NO4S |
| Molar Mass | 389.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nazıroğlu M, et, al. Targeting breast cancer cells by MRS1477, a positive allosteric modulator of TRPV1 channels. PLoS One. 2017 Jun 22;12(6):e0179950. [2]. Kaszas K, et, al. Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J Pharmacol Exp Ther. 2012 Jan;340(1):152-60. |