| Bioactivity | GW-3333 is a potent and orally active TNF-alpha-converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitor. GW-3333 inhibits tumor necrosis factor-alpha (TNF-alpha) production and arthritis[1][2]. |
| In Vivo | GW-3333 在关节炎大鼠模型中抑制踝关节肿胀和关节破坏[1]。GW-3333 (p.o.) 在关节炎大鼠模型中阻断 LPS 后血浆 TNF 的增加长达 12 小时[1]。 |
| Name | GW-3333 |
| CAS | 212609-68-2 |
| Formula | C22H36N4O4 |
| Molar Mass | 420.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Conway JG, et, al. Inhibition of tumor necrosis factor-alpha (TNF-alpha) production and arthritis in the rat by GW3333, a dual inhibitor of TNF-alpha-converting enzyme and matrix metalloproteinases. J Pharmacol Exp Ther. 2001 Sep;298(3):900-8. [2]. Doggrell SA. TACE inhibition: a new approach to treating inflammation. Expert Opin Investig Drugs. 2002 Jul;11(7):1003-6. |