MMP-9-IN-4_product_DataBase

Bioactivity	MMP-9-IN-4 is a MMP-9 inhibitor (IC50: 7.46 nM) that has H-π interactions with MMP-9. MMP-9-IN-4 also inhibits AKT activity (IC50: 8.82 nM). MMP-9-IN-4 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-4 can be used in the research of cancers[1].
Invitro	MMP-9-IN-4 (compound 11, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells[1].MMP-9-IN-4 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 3.6 nM, 3.61 nM, 2.2 nM respectively[1].MMP-9-IN-4 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 3.6 nM, 3.61 nM, 2.2 nM respectively [1].MMP-9-IN-4 (2.2 nM, 24 h) inhibits cell migration in HepG-2 cells[1].MMP-9-IN-4 has anti-bacterial activity against E.coli with a MIC value of 1.814 μM[1]. Cell Viability Assay[1] Cell Line:
Name	MMP-9-IN-4
CAS	2581824-39-5
Formula	C28H19F3N4O6
Molar Mass	564.47
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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