| Bioactivity | MG-115 is a potent and reversible proteasome inhibitor, with Kis of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis[1][2][3]. |
| Invitro | MG-115 (0.1-10 μM; 24 h) dose-dependently decreases the viability of HepG2 cells[3].MG-115 (0.1-10 μM; 24 h) amplifies the reporter gene expression mediated by CWK18 DNA condensates[3]. Cell Viability Assay[3] Cell Line: |
| Name | MG-115 |
| CAS | 133407-86-0 |
| Formula | C25H39N3O5 |
| Molar Mass | 461.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |