| Bioactivity | MARK4 inhibitor 2 is an inhibitor of microtubule affinity-regulating kinase 4 (MARK4) with an Km of 6.3×10 7 and an IC50 of 0.82 μM. MARK4 inhibitor 2 inhibits the growth of human cells and can be used for cancer research[1]. |
| Target | IC50: 0.82 μM (MARK4)Km:6.3×10 7 |
| Invitro | MARK4 inhibitor 2 (Compound 23a) (0-20 μM; 24小时) 抑制 HeLa，U87MG，MDA-MB-435，U251 和 HGFs 细胞的生长，EC50 s 范围从 1.76 μM 到 7.98 μM[1]。 Cell Viability Assay[1] Cell Line: |
| Name | MARK4 inhibitor 2 |
| Formula | C34H30N4O3 |
| Molar Mass | 542.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Maria Voura, et.al. Synthesis, Structural Modification, and Bioactivity Evaluation of Substituted Acridones as Potent Microtubule Affinity-Regulating Kinase 4 InhibitorsACS Pharmacology & Translational Science 2023 6 (7), 1052-1074. |