| Bioactivity | Abz-GIVRAK(Dnp) is the most efficient substrate for cathepsin B and is highly selective for this enzyme among lysosomal cysteine proteases. After Abz-GIVRAK(Dnp) is hydrolyzed, aminoacylbenziminosulfosuccinic acid (Abz-SAS) is released, and dinitrobenzoyl (Dnp) is also released. The product of this hydrolysis reaction, Abz-SAS, is fluorescent under ultraviolet light and can emit a fluorescent signal[1]. |
| Name | Abz-GIVRAK(Dnp) |
| CAS | 827044-38-2 |
| Sequence | {Abz}-Gly-Ile-Val-Arg-Ala-{Lys(Dnp)} |
| Shortening | {Abz}-GIVRA-{Lys(Dnp)} |
| Formula | C41H61N13O12 |
| Molar Mass | 928.00 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cotrin SS, et, al. Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides to define substrate specificity of carboxydipeptidases: assays with human cathepsin B. Anal Biochem. 2004 Dec 15;335(2):244-52. |
Abz-GIVRAK(Dnp)
CAS: 827044-38-2 F: C41H61N13O12 W: 928.00
Abz-GIVRAK(Dnp) is the most efficient substrate for cathepsin B and is highly selective for this enzyme among lysosomal
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