| Bioactivity | M65 TFA is a deleted peptide of maxadilan and is a specific antagonist of PACAP type 1 receptor that inhibits ANP secretion and can be used for relevant researches[1][2]. | ||||||
| Invitro | M65 (1 µM) 完全阻断 100 nM VIP 刺激的 cAMP 积累，部分抑制 1 nM Maxadilan 刺激的大鼠皮质神经元 cAMP 积累[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> M65 TFA 相关抗体: | ||||||
| Sequence | Cys-Asp-Ala-Thr-Cys-Gln-Phe-Arg-Lys-Ala-Ile-Asp-Asp-Cys-Gln-Lys-Gln-Ala-His-His-Ser-Asn-Val-Pro-Gly-Asn-Ser-Val-Phe-Lys-Glu-Cys-Met-Lys-Gln-Lys-Lys-Lys-Glu-Phe-Lys-Ala-NH2 (Disulfide bridge:Cys1-Cys5,Cys14-Cys32) | ||||||
| Shortening | CDATCQFRKAIDDCQKQAHHSNVPGNSVFKECMKQKKKEFKA-NH2 (Disulfide bridge:Cys1-Cys5,Cys14-Cys32) | ||||||
| Formula | C205H326N64O61S5.xC2HF3O2 | ||||||
| Molar Mass | 4823.53 (free base) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Lerner EA, et al. Maxadilan, a PAC1 receptor agonist from sand flies. Peptides. 2007 Sep;28(9):1651-4. [2]. Uchida D, et al. Maxadilan is a specific agonist and its deleted peptide (M65) is a specific antagonist for PACAP type 1 receptor. Ann N Y Acad Sci. 1998 Dec 11;865:253-8. |
M65 TFA
CAS: F: C205H326N64O61S5.xC2HF3O2 W: 4823.53 (free base)
M65 TFA is a deleted peptide of maxadilan and is a specific antagonist of PACAP type 1 receptor that inhibits ANP secret
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