| Bioactivity | Thyroid hormone receptor antagonist (1-850) is a competitive, selective and high-affinity thyroid hormone receptor (TR) antagonist with an IC50 of 1.5 μM for antagonizing the effect of T3 on TR. Thyroid hormone receptor antagonist (1-850) blocks T3-mediated interaction of TRα and TRβ with nuclear receptor coactivator. Thyroid hormone receptor antagonist (1-850) has no effect on the activity of RARα[1][2][3]. |
| Invitro | Thyroid hormone receptor antagonist (1-850) (10 μM；持续 7 天) 消除 Retinoic Acid (RA；HY-14649；1 μM) 诱导的巢蛋白 mRNA 表达增加[2]。Thyroid hormone receptor antagonist (1-850) (0.1-20 μM；24 小时) 可有效阻断器官型罗非鱼肝脏培养物中 IGF1 mRNA 表达，同时增加 D2 mRNA 表达[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Thyroid hormone receptor antagonist (1-850) 相关抗体: |
| CAS | 251310-57-3 |
| Formula | C21H20F3N5O4 |
| Molar Mass | 463.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Matthieu Schapira, et al. Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7354-9. [2]. Mercedes Fernández, et al. Thyroid Hormone Signaling in Embryonic Stem Cells: Crosstalk with the Retinoic Acid Pathway. Int J Mol Sci. 2020 Nov 25;21(23):8945. [3]. Pamela Navarrete-Ramírez, et al. 3,5-di-iodothyronine stimulates tilapia growth through an alternate isoform of thyroid hormone receptor β1. J Mol Endocrinol. 2014 Feb 1;52(1):1-9. |
Thyroid hormone receptor antagonist (1-850)
CAS: 251310-57-3 F: C21H20F3N5O4 W: 463.41
Thyroid hormone receptor antagonist (1-850) is a competitive, selective and high-affinity thyroid hormone receptor (TR)
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