| Bioactivity | Lubiprostone hemiketal (RU-0211 hemiketal; SPI-0211 hemiketal) is a selective chloride channel 2 (CLCN2) activator. Lubiprostone hemiketal is used to treat chronic idiopathic constipation and opioid-induced constipation by activating CLCN2 channels to increase chloride ion secretion in the intestine, thereby increasing intestinal fluid secretion and enhancing intestinal peristalsis. Lubiprostone hemiketal can be used in the study of chronic constipation and cancer[1]. |
| CAS | 333963-40-9 |
| Formula | C20H32F2O5 |
| Molar Mass | 390.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mitsuda M, et al. Functional analysis and clinical significance of chloride channel 2 expression in esophageal squamous cell carcinoma[J]. Annals of Surgical Oncology, 2021, 28: 5384-5397. |
Lubiprostone (hemiketal)
CAS: 333963-40-9 F: C20H32F2O5 W: 390.46
Lubiprostone hemiketal (RU-0211 hemiketal; SPI-0211 hemiketal) is a selective chloride channel 2 (CLCN2) activator. Lubi
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