| Bioactivity | NCOA4-9a inhibits ferroptosis by reducing the amount of bioavailable intracellular ferrous iron through disrupting the nuclear receptor coactivator 4 (NCOA4)−FTH1 (Ferritin) protein−protein interaction. NCOA4-9a inhibits Erastin (HY-15763)-induced ferroptosis, with EC50 of 0.29 μM in HT22 cells[1]. |
| CAS | 2650557-72-3 |
| Formula | C27H28FN5 |
| Molar Mass | 441.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yuying Fang, et al. Inhibiting Ferroptosis through Disrupting the NCOA4−FTH1 Interaction: A New Mechanism of Action. ACS Cent Sci. 2021 Jun 23;7(6):980-989. |