| Bioactivity | Loncastuximab tesirine is a human cluster of differentiation 19 (CD19)-directed antibody-drug conjugate (ADC). Once bound to CD19 on the cell membrane, loncastuximab tesirine is rapidly internalised and triggers cell death. Loncastuximab tesirin induces cell apoptosis, it can be used for the research of diffuse large B-cell lymphoma[1][2]. |
| Invitro | Loncastuximab tesirine 降低了三种人源性 CD19 和 CD79b 阳性 NHL 细胞系 (WSU-DLCL2，TMD8 和 Ramos) 的细胞活力并诱导凋亡，与 polatuzumab vedotin 联合使用效果更好[1]。 |
| Name | Loncastuximab tesirine |
| CAS | 1879918-31-6 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |