| Bioactivity | Citatuzumab bogatox (VB6-845) is recombinant immunotoxin that composed of Fab fragment of humanized antibody targeting EpCAM and a modified cytotoxin bouganin. Citatuzumab bogatox binds to and selectively induces apoptosis in EpCAM-positive cell lines and shows good activity in EpCAM-positive human tumour xenograft models[1][2][3]. |
| Invitro | Citatuzumab bogatox (0-100 nM; 5 days) 抑制 NIH:OVCAR-3 和 CAL-27 细胞的生长，IC50 值均为 3 nM[1]。Citatuzumab bogatox 内化到 EpCAM 表达细胞的细胞质中，然后释放的 Bouganin 通过核糖体失活抑制蛋白质合成，导致癌细胞凋亡[2]。 Cell Viability Assay[1] Cell Line: |
| Name | Citatuzumab bogatox |
| CAS | 945228-49-9 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |