| Bioactivity | YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration[1]. | ||||||||||||
| Name | YZ129 | ||||||||||||
| CAS | 1643120-60-8 | ||||||||||||
| Formula | C19H12N2O2 | ||||||||||||
| Molar Mass | 300.31 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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