| Bioactivity | L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an EC50 value of 0.03μM. L-I-OddU has low cytotoxicity with a CC50 value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis[1][2]. |
| Invitro | L-I-OddU (1 μM; H1 cells) inhibits Epstein-Barr virus (EBV) replication and decreases the linear form of EBV DNA[1].L-I-OddU (0.25-2 μM; 24 h; H1 and L5 cells) has a major metabolite is L-I-OddUMP and increases the amount of the mono- and diphosphate metabolites formed in H1 cells in a dose-dependent manner[1]. |
| Name | L-I-OddU |
| CAS | 207920-87-4 |
| Formula | C8H9IN2O5 |
| Molar Mass | 340.07 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kira T, et, al. Anti-Epstein-Barr virus (EBV) activity of beta-L-5-iododioxolane uracil is dependent on EBV thymidine kinase. Antimicrob Agents Chemother. 2000 Dec;44(12):3278-84. [2]. Focher F, et, al. Antivirals at the mirror: the lack of stereospecificity of some viral and human enzymes offers novel opportunities in antiviral drug development. Curr Drug Targets Infect Disord. 2003 Mar;3(1):41-53. |
L-I-OddU
CAS: 207920-87-4 F: C8H9IN2O5 W: 340.07
L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with
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