| Bioactivity | 2'-Deoxy-L-adenosine is an orally active synthon for modified oligodeoxyribonucleotides. 2'-Deoxy-L-adenosine is a potent, specific and selective inhibitor of the replication of hepatitis B virus (HBV) as well as the closely related duck and woodchuck hepatitis viruses (WHV)[1]. |
| Invitro | 2'-Deoxy-L-adenosine shows anti-hepadnavirus activity, withour affecting the replication of 15 other RNA and DNA viruses, neither nor inhibiting human DNA polymerases (α, β, and γ) or compromise mitochondrial function[1]. |
| In Vivo | 2'-Deoxy-L-adenosine (p.o.; once daily) reduces viral load by as much as 108 genome equivalent/mL serum without drug-related toxicity in woodchuck efficacy model of chronic HBV infection[1]. |
| Name | 2'-Deoxy-L-adenosine |
| CAS | 14365-45-8 |
| Formula | C10H13N5O3 |
| Molar Mass | 251.24 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Standring DN, et al. Antiviral beta-L-nucleosides specific for hepatitis B virus infection. Antivir Chem Chemother. 2001;12 Suppl 1:119-29. |
2'-Deoxy-L-adenosine
CAS: 14365-45-8 F: C10H13N5O3 W: 251.24
2'-Deoxy-L-adenosine is an orally active synthon for modified oligodeoxyribonucleotides. 2'-Deoxy-L-adenosine is a poten
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