| Bioactivity | Keap1-Nrf2-IN-4 is a potent neddylation inhibitor. Keap1-Nrf2-IN-4 exhibits potent anti-proliferation activity against MGC-803 cells (IC50=2.55 µM). Keap1-Nrf2-IN-4 blocks the migration ability and induces apoptosis of gastric cancer cells. Keap1-Nrf2-IN-4 inhibits tumor growth without obvious toxicity[1]. |
| Invitro | Keap1-Nrf2-IN-4 (compound 4g) (72 h) shows anti-proliferation activity (IC50 s of 2.55, 3.88, 3.74, 2.89 µM in MGC-803, MCF-7, A549, HepG-2 cells, respectively)[1].Keap1-Nrf2-IN-4 inhibits neddylation of cullin1, cullin3, cullin5[1].Keap1-Nrf2-IN-4 blocks the migration ability of MGC-803 without cell cycle arrest[1].Keap1-Nrf2-IN-4 (24, 48 h) induces apoptosis of MGC-803 and HGC-27 cells in concentration- and time-dependent manners[1]. Cell Proliferation Assay[1] Cell Line: |
| Name | Keap1-Nrf2-IN-4 |
| Formula | C26H34N2O |
| Molar Mass | 390.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |