| Bioactivity | Ferruginol ((+)-Ferruginol), a natural diterpenoid, is an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial apoptosis. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities[1][2][3]. |
| Invitro | Ferruginol（0-160 μM；24 小时）对甲状腺癌细胞具有有效的抗增殖作用，对 MDA-T32 细胞系的 IC50 为 12 μM。Ferruginol 对正常细胞的毒性作用不太明显[1]。Ferruginol（0-24 μM；24 小时）诱导 MDA-T32 细胞的凋亡性细胞死亡。Ferruginol 剂量依赖性地增加 Bax 表达并降低 Bcl-2 表达[1]。Ferruginol（0-24 μM；24 小时）抑制 MDA-T32 细胞的 MAPK 和 PI3K/AKT 信号通路[1]。Ferruginol（0-24 μM；24 小时）还会引起 ROS 介导的 MDA-T32 细胞基质金属蛋白酶改变[1]。 Cell Viability Assay[1] Cell Line: |
| Name | Ferruginol |
| CAS | 514-62-5 |
| Formula | C20H30O |
| Molar Mass | 286.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |