| Bioactivity | JNJ-10181457 is a selective non-imidazole histamine H3 receptor antagonist that normalizes acetylcholine neurotransmission[1]. |
| In Vivo | JNJ 10181457 (1 mg/kg，i.v.) 在雄性 Wistar 大鼠中，相比于生理盐水对照组，可以阻断组胺 (50 μg/kg) 或甲硫美哌 (50 μg/kg) 产生的迷走神经诱发的心动过缓反应的抑制作用[1]。 |
| Name | JNJ-10181457 |
| CAS | 544707-19-9 |
| Formula | C20H28N2O |
| Molar Mass | 312.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mónica García, et al. Pharmacological Evidence that Histamine H3 Receptors Mediate Histamine-Induced Inhibition of the Vagal Bradycardic Out-flow in Pithed Rats. Basic Clin Pharmacol Toxicol. 2016 Feb;118(2):113-21. |
JNJ-10181457
CAS: 544707-19-9 F: C20H28N2O W: 312.45
JNJ-10181457 is a selective non-imidazole histamine H3 receptor antagonist that normalizes acetylcholine neurotransmissi
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.