| Bioactivity | JH-LPH-33, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. JH-LPH-33 displays outstanding antibiotic activity with a MIC value of 0.66 μg/mL[1]. |
| Invitro | JH-LPH-33 displays IC50 values of 0.026 μM against K. pneumoniae LpxH and 0.046 μM against E. coli LpxH, respectively[1]. JH-LPH-33 potently inhibits bacterial growth at 1.6 μg/mL and displayes a MIC value of >64 μg/mL against E. coli[1]. |
| Name | JH-LPH-33 |
| CAS | 2414590-04-6 |
| Formula | C21H21ClF3N3O3S |
| Molar Mass | 487.92 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cho J, et al. Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4109-4116. |
JH-LPH-33
CAS: 2414590-04-6 F: C21H21ClF3N3O3S W: 487.92
JH-LPH-33, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. J
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.