Antifungal agent 46

CAS: F: C26H28BrF3N4O2 W: 565.43

Antifungal agent 46 (compound 2f) is a potent antifungal agent. Antifungal agent 46 prevents Ras signaling by inhibiting

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Bioactivity	Antifungal agent 46 (compound 2f) is a potent antifungal agent. Antifungal agent 46 prevents Ras signaling by inhibiting protein farnesyltransferase[1].
Invitro	Antifungal agent 46 (compound 2f) inhibits growth at 12.5 μM in biofilm assay, corresponding to a 2-fold higher MIC than Amphotericin B (HY-B0221)[1].
In Vivo	Antifungal agent 46 (compound 2f, 0.78 μM) inhibits FTase activity in vivo[1].
Name	Antifungal agent 46
Formula	C26H28BrF3N4O2
Molar Mass	565.43
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wang Y, et al. Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J Med Chem. 2022 Oct 11.