| Bioactivity | IDH1/2-IN-1 (Compound 6b) serves as a dual inhibitor of IDH1(R132H)/IDH2(R140Q) with IC50 values of 0.22 μM and 1.6 μM, respectively. IDH1/2-IN-1 effectively inhibits tumor growth by suppressing tumor cell proliferation and enhancing host defense through the activation of antioxidant enzymes. Additionally, IDH1/2-IN-1 reduces inflammation and promotes apoptosis, demonstrating robust antitumor activity. IDH1/2-IN-1 holds potential for research in leukemia[1]. |
| Target | IC50: 0.22 μM (IDH1(R132H)). IC50: 1.6 μM (IDH2(R140Q)). |
| Invitro | IDH1/2-IN-1 (Compound 6b) 对 THP1 和 Kasumi 白血病癌细胞表现出优异的抗肿瘤活性，其 IC50 值分别为 10.7 μM 和 10 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> IDH1/2-IN-1 相关抗体: |
| Formula | C26H28N8O6S |
| Molar Mass | 580.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tawfik H O, et al. Rationale design of novel substituted 1, 3, 5-triazine candidates as dual IDH1 (R132H)/IDH2 (R140Q) inhibitors with high selectivity against acute myeloid leukemia: In vitro and in vivo preclinical investigations[J]. Bioorganic Chemistry, 2024, 149: 107483. |