| Bioactivity | CFTR corrector 13 (SVQ18) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector (EC50=3.14 μM). CFTR corrector 13 enhances the function of CFTR channels, especially when used in combination with Lumacaftor (HY-13262), it can produce a dose-dependent increase in CFTR function. CFTR corrector 13 can be used in the study of cystic fibrosis (CF) and other CFTR-related diseases[1]. |
| Formula | C27H25ClN4O4S |
| Molar Mass | 537.03 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Barreca, et al. "Identification of 6, 9-dihydro-5H-pyrrolo [3, 2-h] quinazolines as a new class of F508del-CFTR correctors for the treatment of cystic fibrosis." European Journal of Medicinal Chemistry (2024): 116691. |