| Bioactivity | BI2536-PEG2-Halo is a bifunctional molecule containing a ligand for Halo tag and a Polo-like kinase 1 (PLK1) inhibitor BI-2536 (HY-50698). BI2536-PEG2-Halo inhibits the proliferation of 293T cells with Halo-p53R273H(FL)-mCherry tag (IC50=23 nM), exhibits selective toxicity against p53 mutant cancer cells[1]. |
| Formula | C39H60ClN7O8 |
| Molar Mass | 790.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sadagopan A, et al. p53 protein abundance is a therapeutic window across TP53 mutant cancers and is targetable with proximity inducing small molecules[J]. bioRxiv, 2024: 2024.07. 27.605429. |