| Bioactivity | Hepcidin-1 (mouse) TFA is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) TFA upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) TFA downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) TFA facilitates osteoclast differentiation[1]. | ||||||
| Invitro | Hepcidin-1 (mouse) TFA (200-800 nM，4 天) 促进 RANKL (50 ng/mL) 诱导的 raw264.7 细胞分化[1]。Hepcidin-1 (mouse) TFA (0-800 nM，4 天) 上调 TRAP、CTK 和 MMP-9 mRNA 的表达[1]。Hepcidin-1 (mouse) TFA (0-800 nM，20 小时) 会增加 RAW264.7 细胞中 Trap-5b 蛋白的水平并降低铁转运蛋白 1 (FPN1) 蛋白[1]。 Western Blot Analysis[1] Cell Line: | ||||||
| Name | Hepcidin-1 (mouse) (TFA) | ||||||
| Sequence | Asp-Thr-Asn-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Lys-Cys-Cys-Asn-Asn-Ser-Gln-Cys-Gly-Ile-Cys-Cys-Lys-Thr (Disulfide bridge: Cys7-Cys23,Cys10-Cys22,Cys11-Cys19,Cys13-Cys14) | ||||||
| Shortening | DTNFPICIFCCKCCNNSQCGICCKT (Disulfide bridge: Cys7-Cys23,Cys10-Cys22,Cys11-Cys19,Cys13-Cys14) | ||||||
| Formula | C111H169N31O35S8.xC2HF3O2 | ||||||
| Molar Mass | 2754.24 (free base) | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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| Reference | [1]. Zhao GY, et al. Effects of mouse hepcidin 1 treatment on osteoclast differentiation and intracellular iron concentration. Inflammation. 2015 Apr;38(2):718-27. |
Hepcidin-1 (mouse) (TFA)
CAS: F: C111H169N31O35S8.xC2HF3O2 W: 2754.24 (free base)
Hepcidin-1 (mouse) TFA is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mous
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