| Bioactivity | HGPRT/TBrHGPRT1-IN-1 (Compound 5) is a selective inhibitor targeting human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and Trypanosoma bruce HGPRT1 (TBrHGPRT1) (both Ki=3 nM). HGPRT/TBrHGPRT1-IN-1 ultimately results in decreased cell growth. HGPRT/TBrHGPRT1-IN-1 is primarily used in the research of infectious diseases and cancer[1]. |
| Invitro | HGPRT/TBrHGPRT1-IN-1 的抑制活力分别为 Ki=3 nM (human HGPRT); 10 nM (Pf HGXPRT); 60 nM (Pv HGPRT); 3 nM (TBr HGPRT1); 0.3 μM (Mtb HGPRT); 0.1 μM (Hp XGHPR); 4 μM (Ec XGPRT)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> HGPRT/TBrHGPRT1-IN-1 相关抗体: |
| Formula | C15H24N6O9P2 |
| Molar Mass | 494.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cheshmazar N, et al. Key structural requirements of benzamide derivatives for histone deacetylase inhibition: design, synthesis and biological evaluation. Future Med Chem. 2024 Apr 16. |
HGPRT/TBrHGPRT1-IN-1
CAS: F: C15H24N6O9P2 W: 494.33
HGPRT/TBrHGPRT1-IN-1 (Compound 5) is a selective inhibitor targeting human hypoxanthine-guanine phosphoribosyltransferas
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