HC-067047 hydrochloride

CAS: 1481646-76-7 F: C26H29ClF3N3O2 W: 507.98

HC-067047 hydrochloride is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, r

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Bioactivity	HC-067047 hydrochloride is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 48 nM, 133 nM, and 17 nM, respectively[1].
Invitro	HC-067047 hydrochloride（1 μM；24 小时；HEI-OC1 细胞）处理显着降低高糖培养的 HEI-OC1 细胞中的 mRNA 表达[2]。HC-067047 hydrochloride（1 μM；24 小时；HEI-OC1 细胞）处理显着降低 TRPV4 蛋白的表达[2]。HC-067047 hydrochloride（1 μM；48 小时；HEI-OC1 细胞）处理可抑制细胞增殖[2]。HC-067047 hydrochloride（1 μM；48 小时；HEI-OC1 细胞）处理可促进细胞凋亡[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> HC-067047 hydrochloride 相关抗体:
In Vivo	HC-067047 hydrochloride (0-50 mg/kg；腹腔注射；持续 30 分钟；环磷酰胺治疗的 WT 和 Trpv4-/- 小鼠，以及幼稚 WT 小鼠) 治疗可增加功能性膀胱容量并降低排尿频率在患有膀胱炎的WT小鼠中。HC-067047 hydrochloride 不影响 Trpv4-/- 小鼠的膀胱功能[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1481646-76-7
Formula	C26H29ClF3N3O2
Molar Mass	507.98
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Everaerts W et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9. [2]. Xing Y, et al. Decreased Expression of TRPV4 Channels in HEI-OC1 Cells Induced by High Glucose Is Associated with Hearing Impairment. Yonsei Med J. 2018 Nov;59(9):1131-1137.

HGPRT/TBrHGPRT1-IN-1