PDE1-IN-7_product_DataBase

Bioactivity	PDE1-IN-7 (Compound 13h) is a selective inhibitor of bPDE1 (IC50= 10 nM). PDE1-IN-7 exhibits significant anti-fibrotic effects in a BDL-induced liver fibrosis rat model. PDE1-IN-7 can be used for research in liver fibrosis[1].
Invitro	PDE1-IN-7 (2.5-20μM; 48 h) 能够有效抑制 TGF-β 诱导的 LX-2 细胞成肌纤维细胞分化和增殖[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PDE1-IN-7 相关抗体: Western Blot Analysis[1] Cell Line:
In Vivo	PDE1-IN-7 (i.p.; 2.5 mg/kg; 每天一次，持续 21 天) 在胆管结扎 (BDL) 诱导的肝纤维化大鼠模型中表现出显著的抗纤维化效果[1]。药代动力学分析[1] Route
CAS	3027833-49-1
Formula	C32H36F2N2O6S
Molar Mass	614.70
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhao ZJ, et al. Design, Synthesis, and Evaluation of Dihydropyrimidine Derivatives as Selective PDE1 Inhibitors for the Treatment of Liver Fibrosis. J Med Chem. 2024 Apr 26.

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