| Bioactivity | HDAC6-IN-15 is a selective histone deacetylase 6 (HDAC6) inhibitor. HDAC6-IN-15 has potent inhibitory activity for HDAC6 with IC50 value of 38.2 nM. HDAC6-IN-15 can be used for the research of cancer and neurodegenerative diseases[1]. |
| Invitro | HDAC6-IN-15 (Compound II-5) 对 HDAC6 具有有效的抑制活性，IC50 值为 38.2 nM[1]。HDAC6-IN-15 (50 μL; 48 h) 对 22RV1、MM1.S、MV4-11、JEKO-1 和 4T1 细胞具有抗肿瘤活性，IC50 值分别为 8.90 μM、11.90 μM、7.83 μM、4.80 μM 和 16.51 μM[1]。HDAC6-IN-15（100、200、400、800 nM；24 h）剂量依赖性地诱导乙酰化 a-微管蛋白的积累[1]。HDAC6-IN-15 (5, 10 μM; 24 h) 可诱导细胞凋亡[1]。HDAC6-IN-15（4 mg/mL；48 h）表现出最佳的人血浆稳定性特征[1]。 Cell Proliferation Assay[1] Cell Line: |
| Name | HDAC6-IN-15 |
| Formula | C25H28FFeN3O2 |
| Molar Mass | 477.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jiangkun Yan, et al. Synthesis and bioactivity evaluation of ferrocene-based hydroxamic acids as selective histone deacetylase 6 inhibitors. Eur J Med Chem. 2023 Jan 15;246:115004. |