| Bioactivity | RP-001 is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 induces internalization and polyubiquitination of S1P1. RP-001 has little activity on S1P2-S1P4 and only moderate affinity for S1P5[1]. |
| Invitro | RP-001 elicits dose-dependent lymphopenia of CD4+ T cells. RP-001 induces acute lymphopenia with rapid recovery to untreated levels[1]. |
| In Vivo | RP-001 causes dose-dependent rapid lymphopenia with an EC50 of 0.03 mg/kg[1]. |
| Name | RP-001 |
| CAS | 1306761-53-4 |
| Formula | C24H24N4O4 |
| Molar Mass | 432.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cahalan SM, et al. Actions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in mice. Nat Chem Biol. 2011 May;7(5):254-6. |